Among the evils of the yankee invasion of the South, is the general dissemination of this loathsome disease, which was of rare occurrence South of the Potomac until the Yankees came. Now it is all over the country. Nowhere has it been so prevalent and so fatal as at Knoxville and Nashville, in Tennessee. In the former place it is stated that there have been as many as 2200 cases at one time. As to Nashville, the Dispatch of that place, of Feb’y 7th, states that in Nov’r there were admitted into one hospital 146 cases, in Dec 325, and in January 443. In all 914, of whom 176 were citizens, 270 soldiers, and 449 negroes. In the month of January 114 died, 107 were discharged, and 570 remained under treatment on the 1st of February.
At Norfolk, Va., there are 182 cases of small pox at the pest house.
Source: Fayetteville Observer, March 17, 1864 as found on www.ncecho.org